I started taking Orgovyx in the morning at first and did experience some fatigue in the afternoon. I switched to taking it in the evening and had no fatigue after that...in fact, I had little fatigue in general from my 18 month treatment cycle. I have now been off Orgovyx for 3 weeks and am having only very minor hot flashes and experiencing increased libido. I feel that Orgovyx is a much better choice than Lupron as the side effects leave more quickly after stopping.