Hi Flowergal, My breast cancer was in 1 breast, Ductal Carcinoma 1.5 Cent. small mass. I have been taking anastrozole for 2 years now and the last 6 months have been having some very uncomfortable symptoms. Bone and joints very achy most of the time, nights are worse. Very tired (I teach elementary), hot flashes occasionally. I had 20 days consecutive radiation post surgery. Then this hormone therapy to decrease estrogen in blood stream. I am spending the weekend researching info to help me make a decision to continue, take a break, or stop. The other meds, seem to have greater risks. Oh, I have osteoporosis. Dr. wants me to take the reclast infusion once per year, I've had one does, then a tooth split in 1/2, had to put off any more reclast tx. Yes, this is complicated. I see oncologist Mon. Not sure how it will go.