HI I'm another person who have had a few bouts with very bad GI symptoms including IBSD and wicked reflux. Took rifaximin abt 18 mos ago, felt better for 4 days then IBS came back but eventually went away Why? Now have it again really bad and started rifaximin a week ago, having really intense bloating and reflux, my throat and esophagus are hurting so much, but will stick with the rifaximin for week 2 to see if it helps, but the process this time is really hard. Last time it didn't give me all the extreme bloating and reflux the first week. I have been suffering with various symptoms since getting mild case of covid that mainly affected my GI tract in Dec 2021, so its been more than 2 years now. I have felt better for a few months but then it comes back. I even had thyroid removed which does seem to have helped heart palpitation symptoms, but now my GI tract is really bad. Has anyone tried NAD & increasing therapies, I've been reading about that but have not tried any yet, waiting to see if rifaximin works at all this time.