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Replies to "Positive margins with 3-4 are indicative of the possibility of biochemical recurrence. They are more significant..."
Prostate Cancer | Last Active: May 1 7:21am | Replies (19)
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Positive margins with 3-4 are indicative of the possibility of biochemical recurrence. They are more significant if they are multifocal and greater than 3mm of length. Focal marginal invasion is not indicative of possible BCR. Your doctor will give you a fuller description of the marginal invasion. It may be indicative of the need for further treatment--ADT or radiation. I would want and expect (your doctor will as well) close watch on PSA at 2 and 3 months. And a repeat of the evervaluable PSMA/PET later. Marginal invasion is not indicative of future metastasis.
If you haven't had the somatic testing Decipher, Polaris etc. You might request that it me done now.
Replies to "Positive margins with 3-4 are indicative of the possibility of biochemical recurrence. They are more significant..."
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Thank you for your insights. I am in Canada and actually received the pathology summary online, but have not yet spoken with the urologist who performed the robotic prostatectomy, so I have no clue what he will say, or when. The pathology report does not outline details of the positive margins, so the details you highlight are excellent as questions, so thank you. I have never had a PSMA scan. I had a contrast MRI, followed by a targeted biopsy and the robotic removal. Incontinence is improving, but not ED (low priority for me) but it has only been 4 weeks tomorrow. Best I can tell much reliance will be placed on a 6 week and 3 month PSA screen. Please comment if you feel this is reasonable timing. The availability of advanced screening and targeted radiation approaches in Canada is limited, so I will likely be heading to the US if additional steps need to be taken.