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Prolia and Evenity Together

Osteoporosis & Bone Health | Last Active: May 22 10:31pm | Replies (47)

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@normahorn

I believe you are doing everyone a disservice by claiming that adverse reactions are '"Rare". Personally I want the facts so I can separate what is within the realm of expectation from what is excessive.

This was provided to me by the office of one specialist regarding Evenity. I consider all of these far outside the classification as "rare".

Adverse Reactions

>10%:
Neuromuscular & skeletal: Arthralgia (8% to 13%)

1% to 10%:
Cardiovascular: Cardiac disorder (2%), peripheral edema (2%)
Central nervous system: Headache (5% to 7%), insomnia (2%), paresthesia (1%)
Dermatologic: Skin rash (1%)
Hypersensitivity: Hypersensitivity reaction (7%)
Local: Injection site reaction (5%), pain at injection site (2%), erythema at injection site (1%)
Neuromuscular & skeletal: Muscle spasm (3% to 5%), asthenia (3%), neck pain (2%)

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Replies to "I believe you are doing everyone a disservice by claiming that adverse reactions are '"Rare". Personally..."

You really need to compare the number of adverse events on drug to placebo to see the net effect from the drug. Attached is the table from the Evenity package insert as well as the section on MACE events.

You can find the insert here https://www.pi.amgen.com/-/media/Project/Amgen/Repository/pi-amgen-com/Evenity/evenity_pi_hcp_english.pdf

Don't forget about the adverse events of not taking this or other osteoporosis drugs. A broken hip or spine are pretty bad adverse events.