Low NTx Telopeptide/Creatinine Ratio -24 hour urine

Posted by mikelmarieobri @mikelmarieobri, Apr 18 11:20am

Does anyone have information on what low NTx Telopeptide/Creatinine ratio indicates when there is still significant bone density decline (-7.5% in 18 months)?

What is low turnover osteoporosis?

Thank you!

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mayblin | @mayblin | Apr 18 11:33am

“NTX is usually measured in urine and expressed as a ratio to creatinine to adjust for urinary dilution. The assay for serum NTX shows smaller changes in response to antiresorptive therapy given for osteoporosis and so it has not been widely adopted”.

Here is a paper published for comparison b/t high and low bone turnover op:
https://pubmed.ncbi.nlm.nih.gov/16088360/#:~:text=%22High%20turnover%22%20was%20defined%20as,less%20than%20normal%20osteoblastic%20activity.