It depends somewhat on which chemo recipe you're getting. If you're getting Folfirinox, the ingredient Oxaliplatin is pretty notorious for causing both neuropathy and cold sensitivity (two different things). The cold sensitivity usually goes away a few days after treatment. The nerve damage at the root of the peripheral neuropathy may last a bit longer or even become permanent.

The other common Standard of Care regimen is based on Gemcitabine, often combined with Abraxane, Cisplatin, or both. Cisplatin may have some effect on peripheral neuropathy, but only a fraction of what Abraxane can cause. Abraxane and Cisplatin don't seem to cause the same cold sensitivity as Oxaliplatin.

For the record, I had 12 biweekly rounds of Folfirinox before Whipple, and 32 rounds of Gem+Abrax+Cis since Whipple. I got over the Folfirinox neuropathy within 7 months of stopping. Since I'm still on the GAC, I have new neuropathy from the Abraxane, but it's not terrible (yet).

One "major cancer hospital" I know of does offer ice glove and socks during treatment with Abraxane. I don't know if they do the same with Folfirinox. Another member here said her oncologist at a different institution specifically _avoids_ ice with Folfirinox, but didn't have details as to exactly why. I suspect if your nerves are already hypersensitive to cold from the Oxaliplatin, that adding ice may overload them (like tuning your ears to hear a whisper and then lighting a firecracker, or tuning your eyes to see in the dark and then staring into a laser).

However, compression has also been found to be helpful, and a lot more comfortable. What I've done (not consistently) is put extra-tight surgical gloves on my hands when the Abraxane is going in, and keep them on as long as possible afterward. That makes it easier to play with a phone or turn pages of a book than if you're icing your hands. For my feet I wear compression socks for the same interval, but add ice booties over the socks, so the cold sting is muted a bit. These are fine with Abraxane, but you _might_ be better off with compression only if you're getting the Oxaliplatin with Folfirinox.

You could always ask if they can substitute Cisplatin in place of the Oxaliplatin and reduce the neuropathy risk. They'll look at you like you're stupid, but until they provide a good answer why not, it's not a stupid question. 😉

Wishing you the best with your treatment!