@gently thanks for this- always learning!

"The reductive effect of prior bisphosphonate use (and vitamin D use) are said to equalize to normal response within a year (observed, not proven)."

I am also concerned about the blockage of the SOST pathway and functions of sclerostin throughout the body, including CNS. After Tymlos I have done 4 months and am stopping. That was sort of a compromise plan: to get the burst of bone growth at the beginning of Evenity with minimal time suppressing sclerostin. I hope they are doing more research on suppression of sclerostin in the body.