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After bisphosphonates then what

Osteoporosis & Bone Health | Last Active: Apr 24 12:39am | Replies (21)

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@gently

Serious, you've been on medication that preserve older bone and prevent both remodling and acquisition of new bone. And it has (likely) been effective at preventing fracture. Both reclast and prolia share that mode (by different mechanism) of prevention of bone loss. They are antiresorptive. And I think not adviseable.
Consider Forteo or Tymlos, no matter the bone markers. Redue the markers at 1 month and 2 months. Comparison to baseline is less important than the markers at 1 and 2.
The reductive effect of prior bisphonate use (and vitamin D use) are said to equalize to normal response within a year (observed, not proven).
Unless you have medical reasons prohibiting estrodial replacement, you might consider a patch or bioidentical not instead of but in addition to an anabolic.
I'm finishing a year of Forteo without negative effect and consider it the best on the market.
I will avoid Evenity because of known adverse effect and because of the unknown effect of blockage of the SOST pathway both in the brain and in the cardiovascular system.
Cheers to your endocrinologist. We are all looking for someone with those qualities.
Best luck in your choice of medication.

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Replies to "Serious, you've been on medication that preserve older bone and prevent both remodling and acquisition of..."

@gently what does this sentence mean "The reductive effect of prior bisphonate use (and vitamin D use) are said to equalize to normal response within a year (observed, not proven)." ?