@dkapustin -- I did PRP and you could as well, I would guess. However, I would go with the recommendation of the doctor you will be seeing because each situation is unique. In reality, I was going to get the "stem cell" treatment, but I was on Atorvastatin -- You can't be on Cholesterol-lowering drugs because stem cells do not do well with statins. I couldn't at that time, but now I could be off Statins for a period of time, so I would be a good candidate for Stem Cell treatment. In any event, I will not know until Thursday. About your questions, below are the answers (as they apply to me):
1. Downtime -- Not really. I am retired, so I just took it easy for the rest of the afternoon.
2. Does it hurt -- Yep, but it is NOT an extreme pain. Just think of how much better your knee will feel when the healing starts!!! 😉
3. Conscious Sedation -- I didn't ask! You may want to ask the doctor you will see, during the consultation. I suspect different clinics may have different rules, based on the facilities and personnel available at the clinic.

i did prp with regenexx. took several weeks but really worked. Been told they can do prp once a year if needed. Some small pain the first week.