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Best to listen carefully to reports from patients. Never dismiss them as "horror stories."
When you look at the trials, don't look at abstracts. Look at the studies themselves: how careful the patient selection is; how many patients had to quit the trials; how many actuals end up with their numbers on these neat little charts.
There is one chart reprinted (even here) that resulted from 14 patients, excluding 12 of the 37 originals.
Read the disclaimer on PubMed.
Keep in mind the need of academics to publish, the wealth of pharmaceutical industries. And then remember the generosity of patients here who tell their tragedies only to protect the rest of us.
Replies to "Best to listen carefully to reports from patients. Never dismiss them as "horror stories." When you..."
Hi @gently - Thanks for responding. Of course individual treatment experiences are extremely valuable and I have learned a lot from those experiences. It is tough for a lot of people to share their stories and they are brave to do so.
From a reader perspective, one has to take all experiences with a grain of salt. When placebo adverse events are near equal to on drug events, you have to put everything into perspective. I have read and heard a lot of stories of people getting scared off of treatment just to have a spine or hip break a few years later, and then go on the drug they were scared off of in the first place.
I agree with you on reading trials thoroughly as the devil is in the details for these things. But if you are pushing a T-score of -4.5 and you get convinced that just changing the type of calcium you are taking is going to move the needle, you are headed for disaster.
Just based on what I have learned in the 20 short months since being diagnosed myself. 🙂
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Thank you @gently This is very good advice for reading research.