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Concerned about the side effects of anastrozole

Breast Cancer | Last Active: Apr 27 1:15pm | Replies (1931)

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@windyshores

It is a known fact that aromatase inhibitors like anastrazole cause bone loss.

Menopause causes bone loss through the loss of estrogen. Anastrazole works by reducing estrogen further, below detectable levels.

Were you not put on a bisphosphonate during anastrazole?

Your scores weren't osteoporosis yet, as you know, and they may be borderline now, which can sometimes, for some people, mean no meds yet, but ask an endocrinologist.

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Replies to "It is a known fact that aromatase inhibitors like anastrazole cause bone loss. Menopause causes bone..."

Since I am a diagnosed Type II diabetic, I have been doctoring with an endocrinologist (Texas Endocrine Center) since 2017. I was 7.2 (A1C) and weighed 220 lbs. when I began with them. I am now 5.4 A1C and weigh 180 (and still trying to lose more weight.) I am 78 years old and 5' 2" (shrunk from 5' 2 and 3/4") and I joined a gym, primarily to swim in their heated pool. Unfortunately, the chlorine in the pool is so strong that I can only swim for 30 minutes before I get so dizzy that I fear I will pass out!

I have taken Ozempic AND Mounjaro and seem to have "plateaued" at around 180, which is way off from the insurance charts for people my age and height, which, last time I looked, said 147 lbs. I asked them about my bone density scores, since I knew I had osteopaenia going in. The first ones were obtained thanks to a good OB/GYN who had me get one at 2 year intervals, beginning in 2017.

Last trip in to the endocrinologist she did prescribe something, which, after I read up on it, I did not take. (A pill) I have now had 2 teeth split after routine cleanings. One required a root canal and a crown. That happened during the pandemic in 2020 before my 2021 b.c. diagnosis on Dec. 7, 2021. The second tooth split after cleaning on Nov. 16, 2023. I am in the midst of $12,000 of dental work right now, including a dental implant (#4 tooth), a crown on the tooth next to it, and a new filling under an old filling on a third tooth. I had dental insurance, which chipped in $1,500 for my "annual benefit." I will go in for the "twist test" on April 23 and, if I pass that, the dental implant will be installed. (In the meantime, I have not been able to chew on the right side of my head since November!). When I went to the endodontist (who is a doll!) he said I didn't need a root canal after all ($2,600 if I had), which was good news. He then sent me to "the best oral surgeon in Austin" and we had a very lengthy debate about whether or not I could even have a dental implant. The key thing seemed to be whether I had or had not taken ANY biophosphanates. Although I had filled the prescription, as requested by the Austin Endocrinology people, I never took any of them because I read up on them and it sounded like---given my score(s) then, which were close to osteoporosis but not yet there---I should maybe wait and see. I did, and I'm glad, or I could not have had the dental implant I need(ed) and, with the tooth immediately next to #4 (upper right) needing a crown, bridging was not a very viable option. I am a child of the 40s. I have a mouth full of amalgam fillings, which weaken enamel. Then I was put on Anastrozole for 7 months and my knee blew out and, possibly, it affected my jaw and teeth, as well. I am now taking lots of calcium (morning and night with the K needed) and I've been putting that stuff in my coffee daily that might help build bone---who knows? I also have done extensive reading on the inaccuracies of bone density exams. It seems to depend a lot on what machine is used and exactly how the patient is laid out and whether the patient moves and a whole bunch of other things. All I can say is that, thank God I didn't just swallow that biophosphanate pill when I paid for it and picked it up, or I'd be gumming food without an upper molar from now until the day I die.