I have had sle for 40+ years and have studied and experienced it in depth. Here’s my assessment of your situation: you mentioned you have had signs and symptoms for years. Could you elaborate on those with a ballpark timeline? Many people in your family have exhibited similar symptoms. Were any of them diagnosed with autoimmune diseases? There are lots of possible connections in your case. Many people with sle are allergic to sulfa drugs. Both Lisinopril and HCTZ can cause drug induced lupus. (DIL) Depending on the timeline, what started first, etc I am wondering if you have had symptoms of lupus for years, then perhaps the medication made it worse?
Symptoms of lupus can precede the lab evidence like positive ANA by years. I had signs and symptoms for a decade before my ANA turned barely positive. You really should see a rheumatologist with a timeline, list of all signs and symptoms, when you started the BP meds and family history. Take pictures of any rashes, sores, or color changes in extremities. ANA should be repeated plus a full blown autoimmune panel, anti histone antibodies for DIL, tests for Hashimotos, urine tests, CBC, and basic metabolic panel plus inflammatory markers. A skin biopsy by a dermatologist would help if the sore on shoulder persists. I would encourage you to be proactive and assertive at getting this done. Autoimmune diseases are difficult and rarely follow the textbook course. You’re likely going to be dismissed unless you ask for what you need and persist with finding out what is wrong. Good luck and I hope you get answers soon.