The LDN targets the receptors in the brain that produce dopamine. Research has shown that it attaches to the receptor producing the dopamine and then that is supposed to trigger the brain to produce more or it's own dopamine. I have not had any side effects except a little constipation. I am a recovering alcoholic/addict, so my tolerance to medications might be different. I would not recommend going above 3 mg twice a day and perhaps just start with 3 mg and see how you adjust to it. It is not like SSRI antidepressants. I have been on many and the side effects from those can be hard to tolerate. This is just my opinion about LDN and my experience taking it. I go to a holistic doctor and they have their own pharmacy. If you have that access in your area, I would suggest that but if not, I know that other doctors prescribe LDN. I hope it works for you. It has helped me function better during the day. I wake up feeling like crap, but I am improving over the last two years. The post exertion malaise and the fatigue/inflammation are the worst but once I take the medicine, I feel much better. I haven't found that anything helps with tinnitus. It comes and goes. I hope if you try it, it works for you.