I've been on folfiri for five months. The irinotecan is known for causing diarrhea. The nurses told me the nickname is "I run to can". I use a combination of Lomotil (a prescription drug) and Imodium to control it. The nurses give me atropine before they begin the irinotecan infusion. That controls the diarrhea for about three days for me while I am wearing the infusion pump for the Flourouracil. The day I have the pump removed I begin the lomotil and Imodium combination. If I start having loose stools I take additional Imodium. I hope that helps.