It helps when I take it in the morning. I will feel ok during the day and be able to do more physical activity than when I was not taking it. The issue is that I wake up with the PEM symptoms. That might be because I haven't tried the LDN at night. I may try taking a dose before I go to sleep and see if it makes a difference. For instance, this morning I woke feeling pretty bad but it also depends on what I eat. I can't decide if the fatigue/PEM is worse due to inflammation from what I ate (usually salty or sugar) or due to the virus. I know that the LDN helps me function so much better during the day. I may take a dose before bed tonight and let you know how I feel in the morning.