Good Morning--It seems as though taking the Big 3 is very different for each person responding on this site so changing the times when you take your meds is occasionally necessary. In addition to MAC, I am also dealing with Valley Fever which requires daily Fluconazole which has a negative reaction with Rifampin. I take the Fluconazole, Ethambutol, and my PB Benazapril with breakfast. I take the Azithromycine at noon and then take my Atenolol and Rifampin 2 hours after dinner. I have been taking Fluconazole since June 2023 and the Big 3 since December 2023. I have tolerated all 4 meds very well. I also realize that the severity of MAC is very different for each person and I am fortunate that other than a continual long term cough which is now gone, I have been basically asymptomatic since 2007 when I was first diagnosed. Yes--2007 diagnosed with MAC at Mayo Clinic and offered treatment which I chose not to take. For me, MAC seems to be slow growing. Symptoms have always been the cough. However, since starting the Big 3, I am experiencing a severe body rash and wonder if this can be caused by the meds. I have continually worked on physical fitness, swimming, biking, walking, and pickleball to work on lung and body fitness and believe these have helped me in multiple ways. I have lost weight since starting all the meds but have stableized at 101 lbs. Overall, as an 81 year old I feel I am doing very well.