This is highly dependent on the individual. I've been taking it full dose for one month. I'm a 65-year-old male, 175 pounds, so maybe my experience is going to be different than a smaller, lighter female. I have mild lightheadedness for around 30 minutes, and then it goes away. But, I've read plenty of other experiences here where people have lots of trouble with side effects.

One technique that has worked for some people is to start off with a low dose and then gradually increase it, to give your body a chance to get used to it. The Tymlos pen has a little clickable wheel. If you click it all the way to the max, that's a dose of 80. But, you can also click it just 2-3 times to get a lower dose (I think each click equals another 10.) Given that you'd be taking Tymlos for at least a year, there's no harm in slowly ramping up over the span of a few weeks. Also, some people never get up to the max dose, and they still had good results.

Keep in mind that the people who have trouble with side effects are more likely to post about it on message boards, vs. the people who tolerate the medicine well, so it can give the impression that there are lots of problems with the drug when in fact most people do OK with it. The only way you will know is to try it.