I have idiopathic PN in both feet that has worsened over the past 5 years. It started close to 10 years ago in my left foot, diagnosed only as "metatarsalgia." I have burning, tingling, hot/cold sensation, numbness, and stabbing nerve pain in my toes and the balls of my feet. When we moved to NV in 2021, a neurologist had me try 300mg Gabapentin. I quickly decided I didn't want to stay on it because of the high dose required to relieve pain. So my PCP put me on Pregabalin (Lyrica) at 75mg 3 times a day, and that has helped relieve about 50-60% of my symptoms. Thinking back to when the metatarsalgia in my left foot was getting worse is about the same time my former PCP put me on Imeprazole for GERD. That was probably around 2012, maybe sooner. I've been taking it ever since and never thought about whether there might be a connection between it and my neuropathy! My current PCP who prescribed the Lyrica has never said anything about the long-term use of Imeprazole, so I'm going to mention it to him! Meanwhile, I saw an earlier post about tapering off the PPI and will be following that to the letter! If anyone following this thread happens to see my post, let me know if you've experienced any relief after eliminating the PPI or how doing so has affected your neuropathy pain. I'm hoping soneone has found some relief. I will post my results after tapering off the Imeprazole and giving it some time to see if there is any noticeable difference. I empathize with all who suffer from this miserable condition.