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PSA numbers after radiation with no ADT
Prostate Cancer | Last Active: Apr 8 8:29pm | Replies (14)Comment receiving replies
Bevana00007:
I was diagnosed with the same pathological stage (favorable intermediate risk), after my mpMRI fusion TRUS biopsy in October 2023 (see details in my profile).
I selected (and my urologist agreed) to pursue Active Surveillance, after receiving a Decipher Score on my 3+4 cores of 0.22 (low risk).
Getting a Decipher score is a MUST (IMO) if one is considering AS with this stage (F-IR) of PCa. “High Risk” Decipher Score would have changed my treatment decision.
AS is not the same as “watchful waiting”. If one selects this approach IMHO a program of vigorous exercise and modified diet to reach and maintain an “optimal BMI” (22-23) should be a high priority.
One must also be prepared to pursue other forms of treatment if follow up PSA and biopsies indicate progression.
In my case, my PSA dropped from 7.8 (pre-biopsy) to 5.9 (3 months after biopsy). I lost 25 lbs, during that time period, due to my exercise/diet problem which may have helped??? I’ll know more after my 6 month PSA and a follow up biopsy at 12-18 months after my initial biopsy.
In any case, others will select immediate treatment with this F-IR diagnosis, so every man must decide for themselves, hopefully with the help of a supportive and informative doctor.
All the best as you consider your treatment options.
Alan
Replies to "Bevana00007: I was diagnosed with the same pathological stage (favorable intermediate risk), after my mpMRI fusion..."
As an referenced add-on to my comment, this 2019 study, including Huang and Cooperberg, (“Decipher identifies men with otherwise clinically favorable-intermediate risk disease who may not be good candidates for active surveillance”) is particularly applicable regarding how important a F-IR man’s Decipher Score is for considering an AS decision making.
https://www.nature.com/articles/s41391-019-0167-9One conclusion quoted from the study:
“Men with NCCN F-IR PCa and a low or intermediate Decipher score had similar odds of AP (Adverse Pathology after RP) as men with NCCN VL/LR PCa. Therefore, incorporating Decipher into clinical decision-making, particularly for F-IR PCa, may be useful to safely expand the use of active surveillance.”
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@handera
See you had similiar history. Was at intermediate then had Decipher and went to low risk. I agree the Decipher test is a must. It a much more accurate diagnosis of your cancer risks. I also had bone scan and PSMA which all showed no spread outside prostrate.
I had the proton radiation as it was recommended by both Mayo Clinic and UFHPTI as a cure (hate to use that word maybe best treatment outdome is better) and so far great PSA test.
It is interesting your loss of weight and lower PSA score. Maybe they should research that relationship.