I'm relatively new to these biologics so you have more experience than me.

I didn't have many ill-effects from prednisone when I used high dose Prednisone but only in short term bursts for reactive arthritis and uveitis. I thought PMR was a blessing when I was given a long term prescription for prednisone.

I made many mistakes taking Prednisone for as long as I did. I wish I could have another chance when I was first diagnosed with PMR. I would have advocated for Kevzara or Actemra after a year or two if PMR persisted that long even if there aren't any guarantees. My rheumatologist said a TNF-inhibitor was my other option. Even though Humira didn't work well for me, there was some valuable information that was learned.

All the medical literature says that taking prednisone on a long term basis can cause serious problems.