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Concerned about the side effects of anastrozole
Breast Cancer | Last Active: Nov 21 7:48am | Replies (1935)Comment receiving replies
@vkroger what was your ER score from pathology, and your PR score?
These meds reduce estradiol below detectable levels, by eliminating estradiol produced in the adrenals.
The drug insert for Femara (letrozole) states that a 20% dose achieves that undetectable level. However I am not sure what difference the dose makes and would love to see studies. To me, either estradiol/aromatase is suppressed or it isn't. Even with a 20% dose, if effective, we would have the same symptoms since the symptoms are from estrogen deprivation, right?
That said, try switching manufacturers or switching to a different AI. I ended up taking brand name Femara though at the end I found one generic I could tolerate.
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I’m ER 100% and PR 60%. I’m upset that women get the same dosage of medicine without blood work being done to 1) determine your baseline Estradiol level and 2) periodically check Estradiol levels after being on an AI. Seriously, isn’t monitoring numbers all about research? My Estradiol level is already the lowest in range at < 5, why should I take a full dose of any AI? Women need to question this theory. We are all different and should be treated like individuals … not treated with standard meds. That’s not fair to anyone.