Loss of BMD in hips after taking Forteo or teriparatide?

Posted by lynn59 @lynn59, Mar 29 9:14pm

I’m scheduled to start a biosimilar to Forteo in a couple of weeks and I just read a post today from a woman who lost bone density in her hips after being on Forteo. I got interrupted and couldn’t find the post again, so I’m asking the question here as now I’m afraid to start. My T-score in my spine is -3.1 and my hips are -2.8. I’m borderline whether I need an anabolic and the only reason I’m doing it is because I downhill ski, as well as cross-country and backcountry skiing. I can’t afford to lose in my hips. My endocrinologist warned I may lose in my forearm, but she didn’t say anything about losing in my hips. Now I’m wondering if I should not start it and just go on a Actonel, Reclast or Prolia …. Or do nothing! This is all scaring me silly.

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windyshores | @windyshores | Mar 30 9:34pm

@lynn59 I gained 9% in hip, on Tymlos, going from -3.3 to -2.9. Spine gain was 20% going from -3.7 to -2.5. These are helpful meds for many of us. My doc reminded me too that Forteo and Tymlos improve bone quality- even when bone markers might show, at some point, less anabolic/bone growth activity.

alkaresm | @alkaresm | Mar 30 11:07pm

In reply to @lynn59 "Wow lucky you! Please keep us posted on how you do on it❤️" + (show)

Yes, I will update. Good so far.

alkaresm | @alkaresm | Mar 30 11:17pm

In reply to @thisoldewe "I agree alkaresm... travelling to India for the shot, would still be money in pocket! Thank..." + (show)

Thank you Christine and my best wishes to you too. It is good that you are consulting with the pharmacist. Do let us know what your pharmacist has to say re Gemtide.
You can also get some general information from the pharmacy I use here https://www.1mg.com/drugs/gemtide-injection-714801?wpsrc=Bing+Organic+Search

gently | @gently | Mar 31 1:23am

In reply to @awfultruth "@gently Could you please provide references for your statements about Forteo creating an improvement in bone..." + (show)

awfultruth,
https://jofem.org/index.php/jofem/article/view/382/464 Reflecting "[I]ncrease in cortical porosity through reopening of remodeling space with the removal of older, more mineralized bone and replacement with newer less mineralized bone during treatment with TPP. This article is about the heavier, but weaker bone resulting from bisphosphonate treatment. The reference I'm not locating is a comparison between Tymlos and Forteo. with Tymlos bone being more dense but maybe not an advantage.

lynn59 | @lynn59 | Mar 31 6:26am

In reply to @windyshores "@lynn59 I gained 9% in hip, on Tymlos, going from -3.3 to -2.9. Spine gain was..." + (show)

Thank you for this assurance. You had great gains. May I ask why you are on Evenity after those great gains? Are you really active and prone to fall?

Btw sounds like you have the kind of endocrinologist that I was hoping for.

I hope you are having a nice holiday weekend:)

windyshores | @windyshores | Mar 31 7:40am

In reply to @lynn59 "Thank you for this assurance. You had great gains. May I ask why you are on..." + (show)

I just wanted to boost my femur neck and also "treat to target," meaning get all the scores as close to osteopenia as possible. I attended a masterclass offered by Lani Simpson, back in 2021, where a woman described her gains on Tymlos and her gains on Evenity after Tymlos. I didn't even realize that was not a protocol prescribed by my endos until I requested it. For now, in both practices I go to, I am the only patient doing this. My idea was to do just 3-4 months for a boost, then Reclast. I have since seen studies investigating that kind of use of Evenity, and hope it becomes mainstream in the future. For now, I am my own guinea pig- and my doctors'!

windyshores | @windyshores | Mar 31 7:49am

In reply to @gently "awfultruth, https://jofem.org/index.php/jofem/article/view/382/464 Reflecting "[I]ncrease in cortical porosity through reopening of remodeling space with the removal of..." + (show)

@gently I would love to see the article on Tymlos vs Forteo and porosity. This raises the issues of bone density vs bone quality, and strength vs flexibility. Very interesting. I am particularly interested in the context of compression fractures, which will be hard to find!

gently | @gently | Apr 1 2:45am

In reply to @06111945cc "Why do you say “ Prolia is a hazardous medication?” CC" + (show)

0690945cc https://www.aboutlawsuits.com/prolia/
After Prolia a person has to take another pharmaceutical to counteract fractures certain to happen because of direct after-effect of the drug. During treatment pre osteoclastic cells collect. Immediately after stopping Prolia this collection is released to your bones, causing multiple fracture.
Read the patient comments in the lawsuit link to best understand the dangers.
I consider Forteo the safest, most effective pharmaceutical available for osteoporosis.

sallyj2 | @sallyj2 | Apr 1 9:06am

In reply to @windyshores "@lynn59 I gained 9% in hip, on Tymlos, going from -3.3 to -2.9. Spine gain was..." + (show)

What do they base improved bone quality on? If DEXA drops for some people and they use DEXA to tell us we need treatment, how can they then say the quality is better unless maybe TBS improves? Or, is it based on human bone biopsies?

sallyj2 | @sallyj2 | Apr 1 9:10am

In reply to @gently "0690945cc https://www.aboutlawsuits.com/prolia/ After Prolia a person has to take another pharmaceutical to counteract fractures certain to..." + (show)

Why do you consider Forteo to be safer than Tymlos and what do you like after Forteo? Are we all destined to eventually have risks from busphisphrnates? Hrt supposedly may also holds after Forteo or Tymlos.