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Osteoporosis AND Bone Marrow Disorders

Osteoporosis & Bone Health | Last Active: Apr 11 6:38pm | Replies (21)
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@normahorn

I am not talking about being causative but are treatments contraindicated because of a bone marrow issue. I really like being in stage 0 and do not want anything that might kick me to stage 1 or higher. Or make me more prone to infections.

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Replies to "I am not talking about being causative but are treatments contraindicated because of a bone marrow..."
gently | @gently | Apr 6 11:37am

hi njhornung,
" Higher doses [of bisphosphonate] induced cytotoxicity. . ."
. . . [L]ower concentrations, generated a protective effect from spontaneous and chemotherapy-induced apoptosis, and augmented CLL B cell activation/proliferation. This CLL-activation effect promoted by the BPs was associated with markers of poor CLL prognosis and required the presence of bystander stromal cells.
While the authors aren't positing contraindication, the findings in vitro would be contraindicative of bisphosphonate use for any stage of CLL.

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