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Osteoporosis AND Bone Marrow Disorders

Osteoporosis & Bone Health | Last Active: Apr 11 6:38pm | Replies (21)

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@gently

rola,
there is very little research on CLL and osteoporosis. Both are thought to be conditions of ageing and not interactive or causative either way.
'A recently published study places suspicion on the bisphosphonates as unsafe in low dose and unsafe in higher dose with Cll as it advances the disease. It is a carefully arranged Italian study using human cll cells in petri dishes.
Of the remaining drugs Prolia, Evenity, Tymlos and Forteo, Prolia and Evenity has enough risk factors for everyone, though nothing siginificant is evidenced for CLL.
Of the final two medication Tymlos and Forteo I've found no studies regarding CLL. The nice aspect of both of these drugs is that they leave the body within 24 hours. So if you noticed anything untoward you can simply stop the drug. I'd choose Forteo because of its lower dosage.
You want to be careful that there are no interactions with other medications you are taking.
You may encounter medical providers who are not aware that there is not longer a warning on Forteo for bone cancer. This supposition has been determined incorrect.
You might copy this report for physicians who may not have seen it. The direct relationship between bisphosphonates and CLL is compelling. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10821833/#:~:text=Chronic%20lymphocytic%20leukemia%20(CLL)%20is,treatment%20with%20bisphosphonates%20(BPs). " Unexpected Chronic Lymphocytic Leukemia B cell Activation by Bisphosphonates. . ."
You shouldn't have to struggle for this information on your own. I hope your appointment at Moffit will advantage you.

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Replies to "rola, there is very little research on CLL and osteoporosis. Both are thought to be conditions..."

I am not talking about being causative but are treatments contraindicated because of a bone marrow issue. I really like being in stage 0 and do not want anything that might kick me to stage 1 or higher. Or make me more prone to infections.

Forteo is lower dosage but Tymlos has adjustable doses on the pen with "clicks." Half life of Tymlos and Forteo is 1 hour. Peak action is .25-.52 hours. Forteo peaks in 30 minutes and is gone in 3 hours, pretty much the same as Tymlos. Problem is, these meds need follow up with a bisphosphonate.

@gently Thank you so much for taking the time and trying to help me sort this out. I so respect your understanding and opinion of these complicated issues. The mention of leaving my system in 24hrs makes me more at ease and hopefully with careful monitoring the Dr at Moffit will give me some hope in managing this too. I will definately bring this information with me.

Thank you so very much Gently💓, I appreciate you all so much!