My husband is scheduled for his third Pluvicto infusion in ten days. He was first diagnosed in 2005 and has had metastatic prostate cancer since 2011. He had chemo/docetaxel in 2016, and after that spot radiation and Zytiga kept the cancer at bay and even in remission for years. In late 2023 the metastases started to appear quickly and in many locations on his spine, so Pluvicto was recommended, which he started in January 2024.
You will find the side effects of Pluvicto to be much milder than those after chemo, mostly fatigue and changes in appetite and how appealing food seems. The blood tests and scans you have before and after each Pluvicto infusion will indicate how effective the treatments are against your cancer and how well your body is tolerating them, and you are likely to have a PSMA PET after a few infusions to check how well the Pluvicto is doing.
Pluvicto is a long process over many months, so prepare yourself to hang in there. Good luck to you. Please ask any time you have specific questions.

Thank you for your input. Your husband's experience parallels my own, except for the chemo.
I will report as my treatment continues.

Similar report on side effects for my husband, who has had three Pluvicto treatments with three more to go. Side effects have been much easier to tolerate than chemo -- mostly fatigue for a few days and dry mouth is now ongoing after three treatments but tolerable.
Tips: He was advised by treatment staff to take anti-nausea meds the day of treatment and following. (Take the morning of your treatment to get ahead of nausea). This has worked very well.

Also, my husband requested of the oncologist to have hydration therapy the day following the treatment. He gets an IV following the post-therapy monitoring scan. Although he is actively hydrating by mouth, the post-therapy IV appears to help him combat side effects and ensure that the radiation passes through his body as it needs to.

Good luck with your treatment -- my husband's results have been significant in reducing cancer and preventing progression.

Hi @nhs61, I moved your post to this related discussion:
- Anyone on Pluvicto? Looking for a support team
https://connect.mayoclinic.org/discussion/anyone-on-pluvicto/
I did this so that you connect with others like @eugenelapietra1 @bicio58 @digger @redroadtraveler @kjbushur a@lcoleman3 nd others in addition to the helpful posts you've already received from @lag and @lisab2.

You may also be interested in the discussions I found using the group search:
https://connect.mayoclinic.org/group/prostate-cancer/?search=Pluvicto&index=discussions
@nhs61, how many treatments have you had so far? Any side effects?