My first infusions took about 20 minutes with the only reaction being a combination of fever blisters, mild rosacea like blotching and eczema along with joint pain and mild headaches. The second infusion involved 2 nurses (I am hoping) on each side counting down - 1, 2, 3 - and both infusions finished in a minutes or so. This caused immediate dizziness, doubled the headaches and joint pain and my face became a flaming hot mess of blisters, blotches and itching. Rheumatologist stated to continue the infusions and my dermatologist increased the valtrex. For my third infusion I have spoken to the infusion clinic and requested the slower 20 minute infusions only. If not, I am finished with Evenity.