← Return to Thoughts on Prolia?
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Replies to "I tolerated alendronate very well for 5 years. Now on shots 7 of Evenity. Any reason..."
Do you know of anyone who has successfully come off of Prolia? I have been on it for 2 years. I do have a history of vetebral compression fractures. I was not made aware of the issues of coming off it before I started. My endocrinologist wants me to be on it for at least another year. Dr. McCormack recommends only 2 years. I do wish to come off due to the issues that can arise, however, I am concerned about doing that very thing because of all those same issues. . I am very concerned. Any thoughts.
I've been researching this very question and recently found a study about the different treatment sequences you're discussing. It gets a bit technical, though there are charts included that are very helpful (I'm a visual person).
Here's the link followed by a couple of excerpts that provide an overview:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8567484/
"The primary objective of these post hoc analyses was to compare the probabilities of achieving a T‐score > −2.5 at the total hip or lumbar spine over 3 years with alendronate treatment alone versus treatment sequences of 12 months of romosozumab followed by 2 years of alendronate, or 12 months of romosozumab followed by 2 years of denosumab. An additional objective was to compare the probabilities of achieving non‐osteoporotic BMD T‐scores over 1 year of treatment with romosozumab compared with alendronate."
"After 3 years of treatment, during which those patients initially randomized to romosozumab had switched to either denosumab or alendronate, the probability of reaching a total hip or lumbar spine T‐score above −2.5 was dependent on treatment sequence."
The Evenity website suggests Prolia. Amgen makes both! I see that as sort of like an ad!
My docs use Reclast but alendronate is good too. My docs won't use Prolia because of the risks in getting off.