I had 12 rounds of Folfirinox chemo before Whipple surgery, and have had 30 biweekly rounds of GAC (gemcitabine + nab-paclitaxel / Abraxane + cisplatin) over the last 14 months. I'm stage-IV, but my mets are elsewhere in the abdomen / peritoneum instead of the liver.

I got about 13 months of really good tumor control on the GAC, but the cancer seems to be developing some resistance to it now. The GAC has been much easier for me to tolerate (mostly 2-3 days of fatigue and mild nausea) than Folfirinox was, but I know two people who have had really bad reactions to it.

Everyone is different, but most people tolerate GA well. If you're concerned, you can ask his oncologist about testing him for sensitivity (allergy) to any ingredients before starting. You might also consider starting low; e.g., do only Gem at the 1st treatment, only Abraxane at the 2nd, and then combine them starting on the 3rd. Or if you combine them at the beginning, maybe start at lower doses for the first 1-2 treatments to see how he responds.

Best wishes to you both!

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