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Bone turnover markers (CTX and P1NP): do you have a baseline?

Osteoporosis & Bone Health | Last Active: 59 minutes ago | Replies (109)
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@gently

Interesting drop in P1NP after initiation of Prolia. Supports that suspicion that if Evenity becomes antiresorptive for a longer period than it is anabolic, Prolia might not be the best follow-up medication.

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Replies to "Interesting drop in P1NP after initiation of Prolia. Supports that suspicion that if Evenity becomes antiresorptive..."
Michael Lavacot | @michaellavacot | Apr 15 10:54am

The bone markers while on Evenity were spot on to the trials. Below is a snapshot. While CTX is lowered on Evenity, it is not near as low as on Prolia.

Since my T-scores are still very poor, my only choice after Evenity was Prolia. A bisphosphonate would not be able to get me into a safe zone and I really don't think Tymlos or Forteo would work out for me. That said, I am considering combination Prolia + Tymlos. I will wait a year to see how Prolia is doing on its own first.
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