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Bone turnover markers (CTX and P1NP): do you have a baseline?

Osteoporosis & Bone Health | Last Active: 50 minutes ago | Replies (109)
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@mayblin

Hi @michaellavacot, thank you very much for your reply and sharing your treatment information. To me, your baseline btms showed a very high resorption rate, while p1np is alright. Do you have a known secondary cause for the high resorption rate, may I ask?

Although you had one set of btms during evenity treatment, the changes in both p1np and ctx fell in expection when compared to what manufacturer stated. Did you have a good gain in dexa after 1 year evenity?

Looks like you and your doctor decided on prolia to follow evenity, as Amgen suggested.

Thanks again!

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Replies to "Hi @michaellavacot, thank you very much for your reply and sharing your treatment information. To me,..."
gently | @gently | Mar 28 10:22am

Interesting drop in P1NP after initiation of Prolia. Supports that suspicion that if Evenity becomes antiresorptive for a longer period than it is anabolic, Prolia might not be the best follow-up medication.

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Michael Lavacot | @michaellavacot | Apr 15 10:44am

Hi mayblin, I believe I have high baseline CTX from my hypercalciuria. I'm was peeing out more calcium than I could absorb in a day. While I have lowered urine calcium, it's still way to high at about 350mg/day. I'm still trying to track down the cause. Hopefully this year I will be able to figure it out.

I did not have good outcomes on Evenity. I gained only about 2%. I believe that the results are again related to my high urine calcium. You can't build bone if your net daily calcium is near or below zero.

Prolia seemed like the right choice if not the only choice after Evenity for me. Fingers crossed I can tilt the calcium balance in my favor and see some improvements. I'm taking in about 1500mg or more calcium per day.

Thanks for asking. I have appointment this year with the best nephologist and endocrinologist I could find. They should be able to help me more.

Mike

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