Hello @gardeningjunkie. I moved your discussion and combined it with an existing discussion, "IOVERA for Knee Pain" - https://connect.mayoclinic.org/discussion/iovera/ to meet @bamma9, @ladybug4joints, @leilaninurse, @coffeecupp, @jmos, @josephinecarrion and @kathi65 who have all talked about Iovera as well.

@gardeningjunkie, what sort of therapies have you tried for your knee pain already?

I had Iovera injection 2 weeks before my total knee replacement January 3 , 2023. My surgery and recovery was smooth. I never had any severe pain during my recovery. So i would assume the Iovera injection helped with my recovery and level of pain. My knee was numb from kneecap to mid thigh for over 6 months. It gradually wore off..
Now, February 6, 2024 my sister in law had TKR by same doctor. Insurance no longer paid for the Iovera injection so doctor discontinued using it. My Sister in law had severe pain 2 weeks after her surgery. It’s been 7 weeks for her now her severe pain is getting better. She’s staying with me during recovery so I can help her out when needed. So, i am right here to observe her pain level.
So did the Iovera injection work? From her experience i would say Yes. But, i was asked “did injection work” How would i know if my pain would have been worse? It was my 1st TKR. I had nothing to compare it to. But, when i have left knee done without it i will have a comparison.
Insurance overage is always changing. If they can opp out of paying for something they will.
It’s been 7 weeks now and sister in law doing much better.

Because I have CRPS knee replacement is out. I just had my third zilretta injection. It works for me. I have problems with cortisone but the slow release in zilretta works for me. Medicare will only pay for 2 in a life time. Fortunately my private insurance with prior approval paid for my third. My pain management doctor calls my knee toast but thankfully zilretta allows me the ability to bend it and walk more normally.
.