Plant sterols have above average evidence behind them. My father’s neurologist recommended that because he also can’t tolerate statins. We tried Cholesto-pure by Pure Encapsulations. It’s pricey, but not a statin. The mechanism of action is similar to Zetia (what you’re doctor prescribed). Even natural solutions also have side effects though. It draws out cholesterol through the stool. My dad couldn’t tolerate it because of GI side effects, but he had other co-occurring GI conditions.

I understand and can totally relate to being displeased with the uncertainty and potential side effects, but not everyone experiences those side effects. That said, I’m still very cautious because I know my body and I’m sensitive to medications, even those that are “generally well tolerated,” so it comes down for me to how willing I am to take the risk.

For what it’s worth, most people I know who’ve been on Zetia have had no issues with it, even when they couldn’t tolerate other statins, so it may be worth trying. One strategy I use is to take half of the suggested dose (if it can be done safely). That way I can see how well I tolerate it and if I end up needing less, that’s even better.

His cardiologist also recommended psyllium fiber (Metamucil). That didn’t work for him either, so he used a generic form of the SunFiber supplement—it completely dissolves in anything and has no flavor. The brand we use is Healthy Origins I think—has a yellow cap on it.

You are doing everything right. Our bodies naturally make cholesterol.
Stick with your diet, try not to worry too much.

Hello @jeridenn and welcome to Connect. High cholesterol numbers are concerning because we know how they can affect our cardiovascular system. I had been taking a statin for over 20 years and all of a sudden, my triglycerides, (which had been maintained under 170) hit a high of 300. It was uncertain as to why there was this sudden increase. There had been no change in my weight, lifestyle or stress.

My cardiologist prescribed a prescription-strength Omega 3 medication called Lovaza and in just 30 days the triglycerides were reduced to 120 and the other cholesterol numbers were also reduced. I had no side effects from this medication, and I've continued using it along with a statin prescription. Here is some information about Lovaza from the drugs.com website.

As you well know, everyone reacts to medications differently, I recognize that you might not have the same response as I have had, but if you have not tried this medication, you might consider asking your doctor about it.

I could not tolerate any of the oral statins. Tried them all over a 20 year time span . Tried Repatha and no issues and cut cholesterol by 50% ! Great drug but can be expensive without insurance

I have high VLDL and Lp(a) which seemingly cannot be affected by diet. It is genetic. I was unable to take statins due to muscle issues with every type. I was put on Praluent which worked like a charm in lowering overall cholesterol and especially LDL. No side effects. Then my insurance ceased covering Praluent and I was switched to Repatha. I have not had a blood test since I went on Repatha to be able to assess its effectiveness but I haven't had any side effects.