As with many of the side effects of prednisone people mention on here, yes, I believe I have had thrush. My dentist first brought it up when found white patches in my mouth . I thought I had burned my mouth on some hot food so didn't believe him. Then I had to increase the prednisone during a flare and I had bad pain in my mouth and down into my throat. It made eating difficult. I at first thought it was a side effect of the methotrexate I also take for PMR but believe it was probably thrush. It got better when I lowered the prednisone dose. All I can think of to do is get the doses of both drugs as low as possible.