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← Return to Tymlos vs. Evenity
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Hi. Bread video. Thanks. I’m a 71 yo female. 10 yr estrogen + breast cancer survivor. I find myself with anterolisthesis of L5S1 and lumbar T score of -2.9 and am having pain and numbness down legs into feet. Neurosurgeon won’t do surgery, and I appreciate his honesty, but suggests drug treatment with Tmylos or Forteo to get scores headed in the right direction. After MX I have been getting infusions of alendronate yearly and scores keep falling. Went to my doc to talk about treatment and she brought up Evenity..quicker, faster, etc. my concern is that while I have no heart issues, no high blood pressure , I have a very bad family history of heart disease. My mother died at 54, father had 2 open heart surgeries, died 74. My older sis died of heart attack at age 75. How much weight should I give family history when deciding between Tmylos and Evenity? I like the 12 month treatment plan but I’m reading horrific actual patient experiences with major pain and jaw problems that continue long after treatment stopped.
Replies to "Hi. Bread video. Thanks. I’m a 71 yo female. 10 yr estrogen + breast cancer survivor...."
Hi jaguarqueen - Thanks for the complement. From what I understand from the main Evenity study, it's not necessarily that Evenity increases a chance of heart issues, but that it might be more about the protective response to alendronate. While this might be dated information, you can watch Dr. John Bilezikian discuss this point here https://youtu.be/xJoB_xLZeMs?si=HRUIoZhynJcFPQfc&t=6133 . If you rewind a bit from here, he talks about other adverse effects. If you rewind more, he talks about Tymlos as well.
That said, both drugs are highly effective. The one standout is the performance on hip / femur areas. Evenity excels here. I also know Evenity does well after alendronate, where Tymlos / Forteo struggle a bit, especially in the hip / femur. Attached is a backup slide from my presentation on medications showing the performance of Evenity following bisphosphonates (which would include alendronate).
I personally chose Evenity over Tymlos for two reasons. The performance, especially for the hip / femur area, and because PTH drugs like Tymlos could raise urine calcium. That's not good if you are hypercaliuric, like I am.
Hopefully that helps a bit. Tough decision for sure. I wish you the best of luck.
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Not bread video…good video