When researching this for my husband, I discovered that even a short course of ADT results in the loss of nocturnal erections. That results in loss of regular blood flow through that delicate tissue. After only a few months, the tissue starts to degrade and shrinks. From what I have read, this can't be reversed. There are ways to prevent it happening... a daily dose of cialis 5mg helps to keep the flood flow coupled with daily use of a vacuum pump. By the way, our doctors never told us about this. In fact, most of the immasculating side effects of ADT were NOT even included on the info sheet. We had to find all this out on our own.