It is very heartening to me to hear that you are tolerating the "Big 3". How long have you been taking them? I have an aspergilllus infection as well as MAC with a cavity. I started this week treating the aspergillus. I understand that aspergilllus as well as MAC can cause cavities so we are starting off treating the aspergillus to see if there is any success with closing the cavity. I will move into the Big 3 sometime in the not too distant future and understand I will then be on all 4 medicines for 12-18 months. If the cavity doesn't close, they will consider adding a weekly infusion. This for someone who rarely takes any medicine. Fingers crossed this all works and I can tolerate the medicine. I am very happy to have this group.