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Sudden drop of BMD while on Prolia.

Osteoporosis & Bone Health | Last Active: Mar 25 4:33pm | Replies (32)

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@windyshores

I have not read or been told by anyone that Prolia to Reclast has the same risk rebound as Prolia to Forteo, and have seen in Ben Leder's video on You Tube and Keith McCormick's book "Great Bones" that Forteo is not especially effective after Prolia. You absolutely need to do Reclast. I have been told/read/seen that only Reclast is strong enough to avoid rebound, though aldendronate can be used if you cannot tolerate Reclast.

If you then did Forteo (and the effectiveness would be somewhat less at that point) you would follow with Reclast, not Prolia. Another option would be Evenity between the Reclast treatments. In fact there is a current study on doing 6 months of Evenity, not 12, between other osteoporosis meds- because the first 6 months are bone building and the second 6 months is anti-resorptive like Reclast.

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Replies to "I have not read or been told by anyone that Prolia to Reclast has the same..."

Sorry again. I am better at research than I am with Mayo Connect. Will
improve.

Study in National Library of Medicine. Dated 2/28/21. "Zeledronic Acid
after treatment with Denosaub is associated with bone loss within one
year". Limited sample of 12.

If would be less confusing to me if I only had one MRI or better still two
with comparable trends.

Authors were Kadaru and Shibli-Rahher.