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Prolia black box warning?

Osteoporosis & Bone Health | Last Active: Apr 28 8:56am | Replies (59)
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@thisoldewe

Hi formisc,
Although I have not been told, I am surmising Forteo is the better choice due to lower immune problems and in the past [before I moved to this part of the country] I was treated with truck loads of prednisone, over many years!
The blood work is for CTX, P1NP, Calcium, Vitamin D, and PTH. Will be booked before starting the Forteo and after I am clear of this infection. [ I know that a course of Prednisone would get me over this last bump quickly, but we don't touch that anymore!]

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Replies to "Hi formisc, Although I have not been told, I am surmising Forteo is the better choice..."
formisc | @formisc | Mar 19 7:59pm

Thanks, Christine.

As far as i know, bisphosphonates like Fosamax/Alendronate and Reclast do not affect the immune system unlike Prolia so a possible option would be to transition to one of these anti-resorptives for a short term before starting on Forteo. Personally, i opted for Alendronate as i was not comfortable with the idea of a 12m dose in one go but some choose Reclast because of GERD concerns.

It would be good to specifically discuss the management of any possible Prolia rebound with your doctor as i worry that this and spontaneous fractures could be under-reported and under-estimated.

Oh, on your proposed blood work, those are great choices. The other thing i would include is albumin as it may indicate if your calcium reading needs to be corrected.

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