I also like the idea of throwing the kitchen sink at it early on if you're dealing with locally advanced disease or worse. I had BCR after RP so have hit some nodes that showed mild uptake with 38 fractions of IG/EBRT followed by 2+ years of Orgovyx + abiraterone. My MOs weren't ready to pull the chemo lever for triplet therapy yet based on the results that were recently reporting out of one of the arms of the STAMPEDE trial for the treatment protocol I'm on. They're predicting 75% chance of no BCR at 10 years, which sounds optimistic to me but they're pulling it from one of the premiere clinical trial platforms out there. That would put me at 77 y/o. If I could get those years in relatively good health, put me down for it!