recast infusion for osteoporosis

Posted by ebrezinsky @ebrezinsky, Nov 3, 2022

How safe is a reclast infusion?

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@riddick

Sharing my experience in case it's helpful:Had first Reclast infusion on Monday following a year of Evenity and no prior OP drugs. (Can't do the oral bisphosphonates because of GERD). Six days after the infusion, I'm happy to report that side effects have been minimal, if any. I hydrated as recommended and took Tylenol and Claritin for first 3 days. I was very tired on the second day, maybe slightly feverish, but nothing I would have noticed if I wasn't looking for symptoms. The one thing a bit out of the ordinary was waking up drenched in sweat for the last three days. I'm in mid-70's, in good health, no previous fractures, or auto-immune issues. So far, so good!

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riddick,
That is encouraging! It sounds like you do have some side effects, but they are manageable. 👍

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@normahorn

I also wonder why Evenity does not lock in gain if it goes into anti-resorptive mode. $$$$?

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I think Evenity is anti-resorptive for the last months of the 12 months you are taking it. But it's action lasts only roughly as long as Evenity stays in your body and or as long as the impacted processes in your body are impacted. Then it would go back to normal.

Reclast stays in your bones for years only slowly being removed. It keeps acting to some extent as long as it's there. That can be tracked to some extent with how long does the ctx bone marker of resorption stay lower than it was prior to Reclast. Once the ctx has gone back up you can assume the "locked in" phase is over.

The above is my thinking and is logical but I'm not sure if I've ever seen it stated like that in a scientific paper?

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@riddick

Sharing my experience in case it's helpful:Had first Reclast infusion on Monday following a year of Evenity and no prior OP drugs. (Can't do the oral bisphosphonates because of GERD). Six days after the infusion, I'm happy to report that side effects have been minimal, if any. I hydrated as recommended and took Tylenol and Claritin for first 3 days. I was very tired on the second day, maybe slightly feverish, but nothing I would have noticed if I wasn't looking for symptoms. The one thing a bit out of the ordinary was waking up drenched in sweat for the last three days. I'm in mid-70's, in good health, no previous fractures, or auto-immune issues. So far, so good!

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I also had my Reclast infusion on Friday and had no side effects whatsoever so far except I was a little tired on Saturday.

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@normahorn

I also wonder why Evenity does not lock in gain if it goes into anti-resorptive mode. $$$$?

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That is a good question on the Evenity . I am going into my 8th month and in the donut hole and paying $662 . If it is now in the anti-resorptive mode why don’t they move you into the next steps?

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@riddick

Sharing my experience in case it's helpful:Had first Reclast infusion on Monday following a year of Evenity and no prior OP drugs. (Can't do the oral bisphosphonates because of GERD). Six days after the infusion, I'm happy to report that side effects have been minimal, if any. I hydrated as recommended and took Tylenol and Claritin for first 3 days. I was very tired on the second day, maybe slightly feverish, but nothing I would have noticed if I wasn't looking for symptoms. The one thing a bit out of the ordinary was waking up drenched in sweat for the last three days. I'm in mid-70's, in good health, no previous fractures, or auto-immune issues. So far, so good!

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great to hear

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@susanfalcon52

riddick,
That is encouraging! It sounds like you do have some side effects, but they are manageable. 👍

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Thanks and ---actually more than manageable - hardly noticeable!

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