Sharing my experience in case it's helpful:Had first Reclast infusion on Monday following a year of Evenity and no prior OP drugs. (Can't do the oral bisphosphonates because of GERD). Six days after the infusion, I'm happy to report that side effects have been minimal, if any. I hydrated as recommended and took Tylenol and Claritin for first 3 days. I was very tired on the second day, maybe slightly feverish, but nothing I would have noticed if I wasn't looking for symptoms. The one thing a bit out of the ordinary was waking up drenched in sweat for the last three days. I'm in mid-70's, in good health, no previous fractures, or auto-immune issues. So far, so good!