Opdivo infusion effects vary greatly. I'll assume you're doing infusions once every two weeks, like most do these days. 3 1/2 years ago they just had me do 12 monthly full strength infusions, although the infusion time is still 30 minutes. You just get poked more often... for bloodwork and the infusions (assume you don't have a port since you did not do that type of neoadjuvant chemo regimen).

But I barely noticed any effects of my Opdivo infusions... maybe because I was so busy trying to figure my way forward thru this crazy post-op digestion journey. But I have personally talked with hundreds of other esophagectomy patients... and many also did adjuvant Opdivo. I've seen some have major reactions upon their very first infusion... some had to stop 4 months in, or 6 months, or after 8 months. Some did finish their year of infusions, but just barely, as itchiness and nasty rashes became too much... or joint aches and various other inflammations... very nasty. Also, steroid use to alleviate these side effects became too much of a roller-coaster ride.

But I will say that many, like me, see little to nothing. However you must keep paying attention to what you are seeing, and report anything out of the ordinary to your oncologist asap. For some of us, our immune systems don't like being messed with... and they rebel. As to the benefits we each see from Opdivo, or Keytruda (regardless of our PDL1 expression), hard for me to say. I'm still NED at 4 years now since being diagnosed in March 2020. But what's done it for me? Well I too did Carboplatin and Taxol chemo, radiation, esophagectomy, and my year of Opdivo... I have to assume it was ALL OF THESE THINGS that got me to where I am today as a T3N1M0 EC patient. That, and the biggest factor of all... dumb luck as to how MY body responded to all these things.

Good luck to you sir... you'll see monster changes in your digestion for the next 18 months (at least)... never get down... it is sometimes 3 steps forward and two steps back. And what's not working today may just be fine 3 months from now. Just keep shoving it in... make no concessions to your new stomaphagus arrangement... it will find a way to re-wire itself.