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There are known and documented side-effects with all ADTs. Some are “possible” while others are “likely.” Always focus on the “likely” ones. Most men experience some of these side-effects of hormone therapy to varying degrees — some more, some less —> forgetfulness, confusion, memory loss, mood swings, emotions, fatigue, loss of libido, ED, insomnia, hot flashes, night sweats, muscle atrophy, weight gain, and more….

There are ways to minimize many of these side-effects. Here are videos from recent PCRI conferences about ADT and the physical benefits of exercise:

As for your arthritis…. Similarly, my bone scans, though they are negative for metastatic disease, show (what I could have easily told them) that I have “….degenerative changes in lower lumbar spine and multiple joints (shoulders, sternoclavicular joints, elbows, wrists, knees, ankles, feet, right humeral shaft….likely non-specific and represents a benign process).” Basically, my sports injuries from football, track, gymnastics, and more…..many decades ago have all come back to haunt me now in my 60s.

Still, I push through it because I have to; no excuses.

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Replies to "There are known and documented side-effects with all ADTs. Some are “possible” while others are “likely.”..."

I agree that resistance-training is a very good idea — everyone should follow the advice in this video if physically able — but based solely on personal experience, they overstate the consequences a bit (understandably, because even physicians aren't immune to riding a hobby-horse).

My PC diagnosis was accompanied by paraplegia from the mid spine down (the tumour had compressed my spinal cord), so I wasn't able to do the kind-of complete resistance program they described for many, many months. Certainly, my leg and core muscles atrophied a fair bit (because they were getting almost no nerve signals at all initially), and using my arms to pull myself from side-to-side in the hospital bed gave me some upper-body resistance work, but I didn't see anything like the dire effects they describe during the period when I was starting to become mobile, but couldn't yet get onto the floor or a weight bench for full resistance training.

I did do physio exercises in bed to the best of my ability, and I'm keeping them up now that I'm more mobile, but they were far below the level of weights or push-ups, and I doubt the claim that taking just a 4 week break from 3×/week resistance training would result in massive muscle loss on ADT (at least at my age, mid-50s at the time).