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Sudden drop of BMD while on Prolia.
Osteoporosis & Bone Health | Last Active: Mar 25 4:33pm | Replies (32)Comment receiving replies
@connectalant I posted in another thread on how switching to Tymlos of Forteo if you have been on Prolia more than 1-2 years is not a good idea, based on Great Bones" by Keith McCormick (page 569) and the excellent YouTube by Dr. Ben Leder on Combining and Sequential Approaches to Osteoporosis (minute 35 as I remember). Not only is this switch not effective, according to them, but it can make things worse. These resources and my own doctors say that Reclast is the only med that can avoid the rebound, or possibly to a lesser extent, Fosamax. Or you could stay on Prolia for longer-?
Replies to "@connectalant I posted in another thread on how switching to Tymlos of Forteo if you have..."
The study noting rebound effect with Reclast was "ZA after treatment with Denosumab is associated with bone loss within one year" 2/28/21 National Library of Medicine by Kadaru and Shibli-Rahher.
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I have read the study by Dr. Leder and agree with you. (I will also check the additional references provided by you). My initial thought was to remain on Prolia and to go to Reclast if future DexaScans indicate a further decline in BMD.
The original reason to use Prolia was replace the use of bisphosphonates (after a long drug holiday), which permitted correction of recurring dental problems at 6 month intervals. I am a devoted follower of Dr. Robert Marx. It was not until much later I found that Prolia was a "lifetime" drug. I have been at a high fracture risk level for many years, fortunately with no problems. Going to Forteo or Tymlos and returning to Prolia after two years seemed to be the ideal solution. Finding Dr. Leder's study, however, indicates this would indeed be a poor choice. Unfortunately, there seems to be no perfect solution.