Yes... treatments must be changed once the first line treatments are no longer showing progress. And progress can mean that existing cancer is being held in check... not going away, but also not growing more and spreading more (that is also considered a win). But expect more changes, to Capecitabine pills (Xeloda)... which is a different form of the 5FU he got in Folfox. Also, sometimes the Oxaliplatin is changed out in Folfox for Irinotecan, which now makes the Folfox into Folfiri. And then there is Cisplatin, Carboplatin, Taxotere, Epirubicin, etc. And they may combine these with different immunotherapies as well... even when the patient may not be Her2 positive or show high PDL1 expression.

But still, an uphill battle unless one of these regimens takes care of all spread, and the patient can become surgery eligible. This is rare, but does happen. We just need to see the patient's body and cancer respond to these treatments.