Some people just generate false positives, and when checked with colonoscopy, they’re negative. Go figure.
But, th way I view it is that you cannot afford not to have a colonoscopy to negate the Cologuard results. The appointments and prep are a pain for sure, but this is what I tell myself: There’s only upside to getting the test, because if it’s negative you have piece of mind; and if it’s positive you’re catching it early for the best chance of a healthy recovery. Good luck!