@flusshund, Matthew, Thank you for sharing this news. We know that drug resistance is lurking over our shoulder, ready to show up at some point. We look perfectly healthy and are fortunate to be able to live fairly normal lives on the outside. Friends, coworkers, and even family think we're cured, but we live with this constant weight of recurrence, and sometimes fear. We need the research to stay head of our progression, our lives literally depend on it! Your work helps all of us!
I'm hopeful that taking your dose on a more consistent basis is helpful to push more of the drug to the brain. With Tagrisso and brain progression, do they ever increase the dose? That is a proven success method with ALK and alectinib, although many people aren't able to increase dosage due to side effects too.