Hello Dave,

I'm on the Pluvicto treatment. Chose not to have chemotherapy.

Like you, I have had two Pluvicto sessions and am scheduled for my third this coming Wednesday.

I track my PSA and testosterone levels religiously.

Due to Eligard shots, my testosterone levels had been less than 10 since end of June 2023.

My PSA levels have been June 2023 10.33, July 10.24, August 10.99 rising to 19.08 at the end of August. Since PSA levels started rising, I got another Eligard shot at the end of September. My PSA at end of September was 26.77. End of October it was 39.57 and by the end of December it was 71.16. Although my oncologist disagrees, to me that said the Eligard had stopped working and I elected to discontinue any further Eligard shots. While it may have kept my testosterone levels at less than 10, it did nothing to contain or reduce my rising PSA.

I got my first Pluvicto shot at the end of December 2023 so my "starting" PSA was 71.16. by the end of January my PSA had dropped to 18.02. The first part of February I got my second pluvicto shot and my PSA was 11.81 at that point. My testosterone was still less than 10. I got more readings at the end of February and my PSA had dropped to 6.39 and my testosterone began to rise. It was 14.

Will get new reading next Monday just prior to my third Pluvicto shot on Wednesday.

So that has been my personal experience.

Robert