Hello Dave,

I'm on the Pluvicto treatment. Chose not to have chemotherapy.

Like you, I have had two Pluvicto sessions and am scheduled for my third this coming Wednesday.

I track my PSA and testosterone levels religiously.

Due to Eligard shots, my testosterone levels had been less than 10 since end of June 2023.

My PSA levels have been June 2023 10.33, July 10.24, August 10.99 rising to 19.08 at the end of August. Since PSA levels started rising, I got another Eligard shot at the end of September. My PSA at end of September was 26.77. End of October it was 39.57 and by the end of December it was 71.16. Although my oncologist disagrees, to me that said the Eligard had stopped working and I elected to discontinue any further Eligard shots. While it may have kept my testosterone levels at less than 10, it did nothing to contain or reduce my rising PSA.

I got my first Pluvicto shot at the end of December 2023 so my "starting" PSA was 71.16. by the end of January my PSA had dropped to 18.02. The first part of February I got my second pluvicto shot and my PSA was 11.81 at that point. My testosterone was still less than 10. I got more readings at the end of February and my PSA had dropped to 6.39 and my testosterone began to rise. It was 14.

Will get new reading next Monday just prior to my third Pluvicto shot on Wednesday.

So that has been my personal experience.

Robert

Eligard had been an on and off thing for a couple of years. My experience with it is it knocks my testosterone down, keeps my PSA down for a few months, but is not all that effective in keeping PSA down.

I elected to not have chemotherapy as it made no sense to me to kill off everything and hope that the good came back faster than the bad.

I have had prostate cancer which has metasasized through my bones for several years and have had various treatments including aberaterone and (most recently) Keytruda. At this point everything has basically run it's course and is no longer effective and the allopathic oncologists have run out of things to try. The Pluvecto is their most recent development and so far it is working good for me. When that treatment protocol runs it's course in another five or six months they have nothing more to offer unless there are some new clinical trials which come along.

I am also doing non-fda approved protocols in addition to what the oncologist has to offer and unless there are new allopathic developments I will simply continue with them as my own personal treatment protocol.

I tried to get on the Pluvicto treatment for several months after learning about it as, unlike chemotherapy, it was directly targeting the cancer cells. I was prevented from getting it as soon as I wanted by the FDA guidelines which said a person had to have tried chemotherapy first. Further manufacturer research began to loosen up that restriction so I became one of the first people to get Pluvecto without having gone through chemotherapy.

I stopped after the 3 rd round. My PSA started out around 2.7 and ended up at 20. I said no more.